ICOS: a new costimulatory ligand/receptor pair and its role in T-cell activion.
نویسندگان
چکیده
The inducible costimulator (ICOS) is a new member of the CD28/CD152 receptor family that regulates T-cell activation and function. ICOS binds to a specific ligand on antigen-presenting cells (APC) and cells of the peripheral tissue different from the CD28/CD152 ligands CD80 and CD86. ICOS-L can be induced by inflammatory stimuli in peripheral tissue and on some APC, including monocytes, but is downregulated in B-cell and myeloid leukemia. ICOS-L delivers distinct signals to T cells, presumably important for the maintenance of certain types of immune response, providing the rationale for the development of new therapeutic strategies for the treatment of diseases.
منابع مشابه
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عنوان ژورنال:
- Onkologie
دوره 27 1 شماره
صفحات -
تاریخ انتشار 2004